Danger Signals Triggering Immune Response and Inflammation

Dublin Core

Title

Danger Signals Triggering Immune Response and Inflammation

Subject

Inflammation

Description

The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial or mesenchymal) and injured tissue. Some endogenous danger signals are heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular-matrix breakdown products such as hyaluronan fragments, neuromediators and cytokines like the interferons (IFNs).

Creator

Abdulraouf Ramadan --- Walter G. Land --- Sophie Paczesny

Source

https://www.frontiersin.org/research-topics/4643/danger-signals-triggering-immune-response-and-inflammation

Publisher

Frontiers Media SA

Date

2017

Contributor

Baihaqi

Rights

Creative Commons

Format

PDF

Language

English

Type

Textbooks

Files

Citation

Abdulraouf Ramadan --- Walter G. Land --- Sophie Paczesny , “Danger Signals Triggering Immune Response and Inflammation,” Open Educational Resource (OER) - USK Library, accessed June 21, 2024, http://uilis.usk.ac.id/oer/items/show/2995.

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