NK Cell Subsets in Health and Disease: New Developments

NK Cell Subsets in Health and Disease: New Developments

NK Cell Subsets

Under physiological conditions, the distribution /intensity of the surface markers CD56 and CD16 (FcγRIII) defines two subsets of NK lymphocytes: the CD56bright/CD16neg-dim (generally referred to as CD56bright) population that make up about 10% of blood NK cells in adults and the CD56dim/CD16bright (generally referred to as CD56dim) cells that comprise for about 90% of circulating NK cells. CD56bright NK cells exert only marginal cytotoxic capacity but are higly proficient in production of cytokines such as interferon IFN-γ, TNF-α and GM-CSF. Because of this property, CD56bright NK cells have been generally referred to as regulatory NK cells.

Emanuela Marcenaro, - Luigi D. Notarangelo ,- Jordan S. Orange --- Eric Vivier

https://www.frontiersin.org/research-topics/4350/nk-cell-subsets-in-health-and-disease-new-developments

Frontiers Media SA

2017

Baihaqi

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