Breaking the cycle: Attacking the malaria parasite in the liver

Dublin Core

Title

Breaking the cycle: Attacking the malaria parasite in the liver

Subject

malaria parasite

Description

Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium from the liver. However, malaria liver stage immunity is complex. The anatomic site of priming of naive Plasmodium-specific CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may in fact determine the specificity of the effector CD8 T cells. The participation of particular antigenpresenting cells (Corradin and Levitskaya, 2014) and tissue signatures that influence the activation of intrahepatic CD8 T cells against malaria sporozoites (Morrot and Rodrigues, 2014) are still
incompletely understood. Similarly, how effector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.

Creator

Ute Frevert, Urszula Krzych , Thomas L. Richie

Source

https://www.frontiersin.org/research-topics/2289/breaking-the-cycle-attacking-the-malaria-parasite-in-the-liver

Publisher

Frontiers Media SA

Date

2015

Contributor

Baihaqi

Rights

Creative Commons

Format

PDF

Language

English

Type

Textbooks

Files

Collection

Citation

Ute Frevert, Urszula Krzych , Thomas L. Richie , “Breaking the cycle: Attacking the malaria parasite in the liver,” Open Educational Resource (OER) - USK Library, accessed June 14, 2024, http://uilis.usk.ac.id/oer/items/show/2963.

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