Breaking the cycle: Attacking the malaria parasite in the liver

Breaking the cycle: Attacking the malaria parasite in the liver

malaria parasite

Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium from the liver. However, malaria liver stage immunity is complex. The anatomic site of priming of naive Plasmodium-specific CD8 T cells, be it in the lymph nodes draining the site of Plasmodium antigen deposition by the mosquito or in the liver, may in fact determine the specificity of the effector CD8 T cells. The participation of particular antigenpresenting cells (Corradin and Levitskaya, 2014) and tissue signatures that influence the activation of intrahepatic CD8 T cells against malaria sporozoites (Morrot and Rodrigues, 2014) are still
incompletely understood. Similarly, how effector CD8 T cells detect the few infected hepatocytes in the large liver and the mechanisms they use to kill the intracellular parasites are unknown.

Ute Frevert, Urszula Krzych , Thomas L. Richie

https://www.frontiersin.org/research-topics/2289/breaking-the-cycle-attacking-the-malaria-parasite-in-the-liver

Frontiers Media SA

2015

Baihaqi

Creative Commons

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