Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation

Dublin Core

Title

Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation

Subject

Organ Transplantation

Description

In recent years, there has been vast improvement in the survival of solid organ grafts. Improved
immunosuppression has resulted in efficient control of cell-mediated immune responses and has also
mitigated the effects of HLA mismatching between the recipient and the grafted organ. ntibodymediated
rejection (AMR) however still remains a clinical
challenge and the identification of donorspecific
HLA antibodies pretransplant are a mandatory
requirement for successful grafting. Accurate and
sensitive HLA antibody identification has been made
possible by the introduction of solid phase assays
such as the Luminex bead based platform for antibody testing. Despite this advancement in detecting and understanding the role of HLA antibodies in rejection, many questions still require answers in order to maximize the outcome in solid organ transplantation. Many of these aspects are
dealt with efficiently in this excellent series of papers
addressing the role of antibodies in solid organ
rejection. This collection of reviews, some including new findings, by world leaders in their particular

Creator

Narinder K. Mehra --- Ajay Kumar Baranwal --- Brian D. Tait

Source

https://www.frontiersin.org/research-topics/4209/antibody-repertoire-and-graft-outcome-following-solid-organ-transplantation

Publisher

Frontiers Media SA

Date

2017

Contributor

Baihaqi

Rights

Creative Commons

Format

PDF

Language

English

Type

Textbooks

Files

Citation

Narinder K. Mehra --- Ajay Kumar Baranwal --- Brian D. Tait, “Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation,” Open Educational Resource (OER) - USK Library, accessed June 21, 2024, http://uilis.usk.ac.id/oer/items/show/2951.

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