Innovative Medicine : Basic Research and Development
Dublin Core
Title
Innovative Medicine : Basic Research and Development
Subject
Medicine
Description
Reactive oxygen species (ROS) are an intricate part of normal cellular physiology. In excess, however, ROS can damage all three major classes of acromolecules and compromise cell via bility. We briefl y discuss the physiology of ROS but focus on the mechanisms cells use to preserve redox homeostasis upon oxidative
stress, with particular emphasis on glycolysis. ROS inhibits multiple glycolytic enzymes, including glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase M2, and phosphofructokinase-1. Consistently, glycolytic inhibition promotes fl ux into the oxidative arm of the pentose phosphate pathway to generate NADPH. NADPH is critically important, as it provides the reducing power that fuels the protein-based antioxidant systems and recycles oxidized glutathione. The unique ability of pyruvate kinase M2 inhibition to promote serine synthesis in the context of oxidative stress is also discussed.
stress, with particular emphasis on glycolysis. ROS inhibits multiple glycolytic enzymes, including glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase M2, and phosphofructokinase-1. Consistently, glycolytic inhibition promotes fl ux into the oxidative arm of the pentose phosphate pathway to generate NADPH. NADPH is critically important, as it provides the reducing power that fuels the protein-based antioxidant systems and recycles oxidized glutathione. The unique ability of pyruvate kinase M2 inhibition to promote serine synthesis in the context of oxidative stress is also discussed.
Creator
Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto
Source
https://link.springer.com/content/pdf/10.1007%2F978-4-431-55651-0.pdf
Publisher
springer.com
Date
2015
Contributor
Baihaqi
Rights
Creative Commons
Format
PDF
Language
English
Type
Textbooks
Files
Collection
Citation
Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto, “Innovative Medicine : Basic Research and Development,” Open Educational Resource (OER) - USK Library, accessed October 9, 2024, http://uilis.usk.ac.id/oer/items/show/2907.