Innovative Medicine : Basic Research and Development

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Title

Innovative Medicine : Basic Research and Development

Subject

Medicine

Description

Reactive oxygen species (ROS) are an intricate part of normal cellular physiology. In excess, however, ROS can damage all three major classes of acromolecules and compromise cell via bility. We briefl y discuss the physiology of ROS but focus on the mechanisms cells use to preserve redox homeostasis upon oxidative
stress, with particular emphasis on glycolysis. ROS inhibits multiple glycolytic enzymes, including glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase M2, and phosphofructokinase-1. Consistently, glycolytic inhibition promotes fl ux into the oxidative arm of the pentose phosphate pathway to generate NADPH. NADPH is critically important, as it provides the reducing power that fuels the protein-based antioxidant systems and recycles oxidized glutathione. The unique ability of pyruvate kinase M2 inhibition to promote serine synthesis in the context of oxidative stress is also discussed.

Creator

Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto

Source

https://link.springer.com/content/pdf/10.1007%2F978-4-431-55651-0.pdf

Publisher

springer.com

Date

2015

Contributor

Baihaqi

Rights

Creative Commons

Format

PDF

Language

English

Type

Textbooks

Files

Citation

Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto, “Innovative Medicine : Basic Research and Development,” Open Educational Resource (OER) - USK Library, accessed May 21, 2024, http://uilis.usk.ac.id/oer/items/show/2907.

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